Sulfhydryl-Directed Iridium-Catalyzed C-H/Diazo Coupling and Tandem Annulation of Naphthalene-1-thiols.
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DOI: 10.1021/acs.orglett.9b02581
Abstract: The first sulfhydryl-directed iridium-catalyzed C-H/diazo coupling and tandem annulation of naphthalene-1-thiols has been developed. The framework of naphtho[1,8-bc]thiopyrans was constructed in a one-step reaction with good yields. This transformation provides a practical synthetic route for… read more here.
Keywords: diazo coupling; catalyzed diazo; directed iridium; iridium catalyzed ... See more keywords
Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp2)–H allylic alkylation of α,β-unsaturated carbonyls
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03966d
Abstract: Hydroxy-directed iridium-catalyzed enantioselective formal β-C(sp2)–H allylic alkylation of kojic acid and structurally related α,β-unsaturated carbonyl compounds is developed. This reaction, catalyzed by an Ir(i)/(P,olefin) complex, utilizes the nucleophilic character of α-hydroxy α,β-unsaturated carbonyls, to introduce… read more here.
Keywords: enantioselective formal; hydroxy; directed iridium; iridium catalyzed ... See more keywords