Articles with "directed lithiation" as a keyword



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Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether

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Published in 2023 at "Molecules"

DOI: 10.3390/molecules28030932

Abstract: Pyrrolopyrimidines are important scaffolds for the preparation of bioactive molecules. Therefore, developing efficient and flexible ways for selective functionalization of the pyrrolopyrimidine skeleton is of interest. We have investigated lithiation-addition at C-6 of protected 4-chloro-7H-pyrrolo… read more here.

Keywords: lithiation; addition; dimethylaminoethyl ether; directed lithiation ... See more keywords