Computational analysis of PTP-1B site-directed mutations and their structural binding to potential inhibitors.
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DOI: 10.14715/cmb/2022.68.7.13
Abstract: Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obesity as it suppresses insulin and leptin signaling. PTP-1B deletion or pharmacological suppression boosted glucose homeostasis and insulin signaling without altering hepatic fat… read more here.
Keywords: ptp inhibitors; directed mutations; site directed; computational analysis ... See more keywords