Remote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes.
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DOI: 10.1021/jacs.2c05993
Abstract: Despite the frequent occurrence of γ-branched amines in bioactive molecules, the direct catalytic asymmetric synthesis of this structural motif containing a remote stereocenter remains an important synthetic challenge. Here, we report an amide-directed, rhodium-catalyzed highly… read more here.
Keywords: directed rhodium; remote stereocenter; enantioselective hydroboration; rhodium ... See more keywords