Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad098
Abstract: Abstract A major challenge confronting the clinical application of site-directed RNA editing (SDRE) is the design of small guide RNAs (gRNAs) that can drive efficient editing. Although many gRNA designs have effectively recruited endogenous Adenosine… read more here.
Keywords: rna editing; site directed; selection assay; directed rna ... See more keywords
Site-directed A → I RNA editing as a therapeutic tool: moving beyond genetic mutations
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079518.122
Abstract: Adenosine deamination by the ADAR family of enzymes is a natural process that edits genetic information as it passes through messenger RNA. Adenosine is converted to inosine in mRNAs, and this base is interpreted as… read more here.
Keywords: rna editing; site directed; editing therapeutic; directed rna ... See more keywords
Development of a Single Construct System for Site-Directed RNA Editing Using MS2-ADAR
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144943
Abstract: Site-directed RNA editing (SDRE) technologies have great potential for treating genetic diseases caused by point mutations. Our group and other researchers have developed SDRE methods utilizing adenosine deaminases acting on RNA (ADARs) and guide RNAs… read more here.
Keywords: directed rna; single construct; site directed; rna editing ... See more keywords