Post-Assembly Modification of Head-to-Tail Cyclic Peptides by Methionine-Directed β-C(sp3)-H Arylation.
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DOI: 10.1021/acs.orglett.2c02253
Abstract: Peptide modification by C(sp3)-H functionalization of internal residues remains a major challenge due to the inhibitory effect of peptide bonds. In this work, we developed a methionine-directed β-C(sp3)-H arylation method for internal alanine functionalization. By… read more here.
Keywords: methionine directed; directed sp3; head; head tail ... See more keywords
Directed C(sp3)–H arylation of tryptophan: transformation of the directing group into an activated amide
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DOI: 10.1039/c9sc03440d
Abstract: The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time. read more here.
Keywords: transformation directing; sp3 arylation; arylation tryptophan; directed sp3 ... See more keywords
Merging directed sp3 and nondirected sp2 C–H functionalization for Pd-catalyzed polydeuteration of (hetero)arenes
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DOI: 10.1039/d5sc01407g
Abstract: Polydeuteration has emerged as a key strategy in the development of pharmaceuticals and functional organic materials, advancing beyond monodeuteration and trideuteromethylation. We have developed methods for the polydeuteration of a wide range of organic compounds… read more here.
Keywords: nondirected sp2; merging directed; functionalization; directed sp3 ... See more keywords