Post-Assembly Modification of Head-to-Tail Cyclic Peptides by Methionine-Directed β-C(sp3)-H Arylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02253
Abstract: Peptide modification by C(sp3)-H functionalization of internal residues remains a major challenge due to the inhibitory effect of peptide bonds. In this work, we developed a methionine-directed β-C(sp3)-H arylation method for internal alanine functionalization. By… read more here.
Keywords: methionine directed; directed sp3; head; head tail ... See more keywords
Directed C(sp3)–H arylation of tryptophan: transformation of the directing group into an activated amide
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc03440d
Abstract: The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time. read more here.
Keywords: transformation directing; sp3 arylation; arylation tryptophan; directed sp3 ... See more keywords