Activity‐Directed Synthesis: A Flexible Approach for Lead Generation
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DOI: 10.1002/cmdc.202000524
Abstract: Activity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses… read more here.
Keywords: activity directed; lead generation; directed synthesis; approach ... See more keywords
Precursor‐Directed Synthesis of Apoptosis‐Initiating N‐Hydroxyalkyl Phenylbenzoisoquinolindione Alkaloids
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DOI: 10.1002/open.202200157
Abstract: Abstract A precursor‐directed approach to access N‐hydroxyalkyl phenylbenzoisoquinolindiones (PBIQs) has been developed. Incubation of plant material of Xiphidium caeruleum with hydroxylamines of various chain lengths (C2, C4, C6, C8, C10 and C12) resulted in 11… read more here.
Keywords: synthesis apoptosis; hydroxyalkyl; apoptosis initiating; directed synthesis ... See more keywords
Effect-Directed Synthesis of PhoP/PhoQ Inhibitors to Regulate Salmonella Virulence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01087
Abstract: Salmonella spp. are among the leading bacterial causes of foodborne infections. The PhoP/PhoQ two-component regulatory system serves as a master virulence regulator in Salmonella. Although PhoP/PhoQ represents an ideal target for disarming Salmonella virulence, it… read more here.
Keywords: phop phoq; salmonella virulence; directed synthesis; effect directed ... See more keywords
3D-QSAR-Directed Synthesis of Halogenated Coumarin-3-Hydrazide Derivatives: Unveiling Their Potential as SDHI Antifungal Agents.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c00200
Abstract: The pursuit of new succinate dehydrogenase (SDH) inhibitors is a leading edge in fungicide research and development. The use of 3D quantitative structure-activity relationship (3D-QSAR) models significantly enhances the development of compounds with potent antifungal… read more here.
Keywords: qsar directed; hydrazide derivatives; coumarin hydrazide; directed synthesis ... See more keywords
Ligand-directed synthesis of {Mn} twisted bow-ties.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt02430d
Abstract: Two isostructural polymetallic complexes [Mn(μ3-O)2(CH3COO)4(L1)4]- and [Mn(μ3-O)2(CH3COO)4(L2)4]- have been synthesised by using two Schiff base ligands derived from 3,5-diamino-1,2,4-triazole, following two different preparative routes, either using the pre-formed ligand (for L1) or via a metal-mediated… read more here.
Keywords: twisted bow; synthesis twisted; ligand directed; synthesis ... See more keywords
Seed-directed synthesis of chiroptically active Au nanocrystals of varied symmetries.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04126j
Abstract: Chiral plasmonic nanocrystals with varied symmetries were synthesized by L-glutathione-guided overgrowth from Au tetrahedra, nanoplates, and octahedra, highlighting the importance of chiral molecule adsorption at transient kink sites. Large g-factors are possible and depend on… read more here.
Keywords: synthesis chiroptically; seed directed; directed synthesis; varied symmetries ... See more keywords