Host-directed therapies to combat tuberculosis and associated non-communicable diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.03.003
Abstract: Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the immune system in multiple ways. Mtb is an enormously successful human pathogen that can remain undetected in hosts for decades without… read more here.
Keywords: communicable diseases; non communicable; host directed; directed therapies ... See more keywords
A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piab123
Abstract: Abstract Background It is unclear how acute coronavirus disease 2019 (COVID-19)-directed therapies are used in children with life-threatening COVID-19 in US hospitals. We described characteristics of children hospitalized in the intensive care unit or step-down… read more here.
Keywords: directed therapies; intensive care; covid; covid directed ... See more keywords
SAT-330 Preclinical Screen of Patient CRPC Tumors Shows Sensitivity to Bromodomain Inhibitors Includes AR-null and Neuroendocrine Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-330
Abstract: Abstract Castration-resistant prostate cancer (CRPC) remains a lethal disease despite the introduction of second generation androgen receptor (AR) directed therapies. Resistance to AR directed therapies, such as abiraterone and enzalutamide, emerges through diverse alterations in… read more here.
Keywords: patient; directed therapies; bet inhibitors; null neuroendocrine ... See more keywords
Host Directed Therapies for Tuberculous Meningitis.
Sign Up to like & getrecommendations! Published in 2020 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.16474.1
Abstract: A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes. Currently only one HDT, dexamethasone, is proven… read more here.
Keywords: therapies tuberculous; directed therapies; tuberculous meningitis; host ... See more keywords
Recent Advances in Host-Directed Therapies for Tuberculosis and Malaria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.905278
Abstract: Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, and malaria, caused by parasites from the Plasmodium genus, are two of the major causes of death due to infectious diseases in the world. Both diseases are… read more here.
Keywords: host directed; tuberculosis; tuberculosis malaria; recent advances ... See more keywords
Pituitary-Directed Therapies for Cushing’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00164
Abstract: Cushing’s disease (CD) is caused by a pituitary corticotroph neuroendocrine tumor inducing uncontrolled hypercortisolism. Transsphenoidal surgery is the first-line treatment in most cases. Nonetheless, some patients will not achieve cure even in expert hands, others… read more here.
Keywords: cushing disease; inhibitor; therapies cushing; disease ... See more keywords
Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00417
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is one of the most prevalent lung infections of humans and kills ~1.7 million people each year. TB pathophysiology is complex with a central role played by granuloma… read more here.
Keywords: host directed; directed therapies; neutrophils close; environment ... See more keywords
Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00808
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects… read more here.
Keywords: directed therapies; errors immunity; inborn errors; hlh ... See more keywords
Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01553
Abstract: Tuberculosis (TB) has been a transmittable human disease for many thousands of years, and M. tuberculosis is again the number one cause of death worldwide due to a single infectious agent. The intense 6- to… read more here.
Keywords: host directed; directed therapies; tuberculosis; host ... See more keywords
The New Frontier of Host-Directed Therapies for Mycobacterium avium Complex
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.623119
Abstract: Mycobacterium avium complex (MAC) is an increasingly important cause of morbidity and mortality, and is responsible for pulmonary infection in patients with underlying lung disease and disseminated disease in patients with AIDS. MAC has evolved… read more here.
Keywords: avium complex; host directed; directed therapies; host ... See more keywords
Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.733853
Abstract: Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the world threatens national TB control programs. This… read more here.
Keywords: targeting molecular; host directed; directed therapies; inflammatory ... See more keywords