The effect of early goal‐directed therapy for treatment of severe sepsis or septic shock: A systemic review and meta‐analysis☆,☆☆
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DOI: 10.1016/j.jcrc.2016.10.019
Abstract: Purpose: To assess the effects of early goal‐directed therapy (EGDT) on reducing mortality compared with conventional management of severe sepsis or septic shock. Materials and methods: We included a systemic review, using the Medline and… read more here.
Keywords: directed therapy; sepsis; early goal; severe sepsis ... See more keywords
Catheter-directed therapy as a treatment for submassive pulmonary embolism: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Life sciences"
DOI: 10.1016/j.lfs.2017.08.031
Abstract: AIMS Catheter-directed therapy (CDT) is included in the guidelines for diagnosing and treating massive pulmonary embolism. However, few studies have evaluated the efficacy of CDT as a treatment for submassive pulmonary embolism (SPE). Therefore, we… read more here.
Keywords: catheter directed; directed therapy; pulmonary embolism; cdt ... See more keywords
The use of thalidomide to treat children with tuberculosis meningitis: A review.
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DOI: 10.1016/j.tube.2021.102125
Abstract: Much of the morbidity and mortality caused by tuberculous meningitis (TBM) is mediated by a dysregulated immune response. Effective host-directed therapy is therefore critical to improve survival and clinical outcomes. Currently only one host-directed therapy… read more here.
Keywords: meningitis; directed therapy; use; host directed ... See more keywords
Adjuvant chemotherapy and HER-2-directed therapy for early-stage breast cancer in the elderly
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DOI: 10.1038/bjc.2016.360
Abstract: There is a lack of sufficient evidence-based data defining the optimal adjuvant systemic therapies in older women. Recommendations are mainly based on retrospective studies, subgroup analyses within larger randomised trials and expert opinion. Treatment decisions… read more here.
Keywords: chemotherapy; directed therapy; adjuvant chemotherapy; cancer ... See more keywords
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients
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DOI: 10.1080/07357907.2022.2139839
Abstract: Abstract TMPRSS2 is utilized by SARS-CoV-2 for cellular entry. Androgen-Androgen receptor directed therapy (A/ARDT) downregulates expression of TMPRSS2. We hypothesized A/ARDT might protect prostate cancer (PCa) patients from poor COVID-19 outcome. A retrospective analysis of… read more here.
Keywords: directed therapy; receptor directed; androgen receptor; androgen ... See more keywords
Autophagy: A new strategy for host-directed therapy of tuberculosis
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DOI: 10.1080/21505594.2018.1536598
Abstract: ABSTRACT Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort has been made to develop novel/improved therapies by modulating host responses… read more here.
Keywords: directed therapy; host directed; tuberculosis; host ... See more keywords
Early Goal-Directed Therapy for Sepsis: A Novel Solution for Discordant Survival Outcomes in Clinical Trials
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DOI: 10.1097/ccm.0000000000002235
Abstract: Objectives: Early goal-directed therapy has shown discordant survival outcomes in sepsis studies. We aim to find the reasons for this discordance. Design: Random-effects and Bayesian hierarchical analyses. Setting: Studies that evaluated early goal-directed therapy. Subjects:… read more here.
Keywords: directed therapy; goal; risk; early goal ... See more keywords
Early haemorrhage control and management of trauma-induced coagulopathy: the importance of goal-directed therapy
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DOI: 10.1097/mcc.0000000000000466
Abstract: Purpose of review The aim of this study was to discuss the recent developments in trauma-induced coagulopathy and the evolvement of goal-directed therapy. Recent findings Mortality from major trauma continues to be a worldwide problem,… read more here.
Keywords: directed therapy; trauma; trauma induced; goal directed ... See more keywords
Radiotherapy as metastasis-directed therapy for oligometastatic prostate cancer
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DOI: 10.1097/mou.0000000000000441
Abstract: Purpose of review To summarize the available literature regarding radiotherapy as a metastasis-directed therapy (MDT) in the treatment of oligometastatic prostate cancer (PCa). Recent findings Three different clinical scenarios of oligometastatic PCa exist in which… read more here.
Keywords: directed therapy; radiotherapy metastasis; oligometastatic prostate; pca ... See more keywords
Patterns of recurrence in genuine and induced oligometastatic castration‐resistant prostate cancer treated with progressive site‐directed therapy
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DOI: 10.1111/iju.15090
Abstract: To describe oncological outcomes after progressive site‐directed therapy (PSDT) in genuine and induced oligometasatic (OM)‐castration‐resistant prostate cancer (CRPC). read more here.
Keywords: genuine induced; directed therapy; site directed; resistant prostate ... See more keywords
What is the clinical utility of next generation sequencing (NGS) in advanced urologic malignancies?
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DOI: 10.1200/jco.2019.37.7_suppl.285
Abstract: 285 Background: Widespread availability of NGS and an expanding repertoire of targeted therapies has garnered significant enthusiasm for the concept of NGS directed therapy. FoundationOne (Foundation Medicine, Cambridge, MA) is a validated comprehensive genomic profiling… read more here.
Keywords: ngs directed; duration; cancer; urothelial kidney ... See more keywords