Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Chem"
DOI: 10.1016/j.chempr.2017.11.002
Abstract: Summary The development of methods for the functionalization of otherwise inert C–H bonds is one of the major foci in molecular syntheses. Recent advances have significantly improved the arsenal of synthetic chemistry, enabling the use… read more here.
Keywords: directing groups; groups transformative; metal; transformative activation ... See more keywords
Ketones as directing groups in photocatalytic sp3 C–H fluorination† †Electronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02703f
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc02703f
Abstract: Visible light-sensitization allows conformationally rigid ketones to act as “directing groups” for aliphatic fluorination using Selectfluor, catalytic benzil, and LEDs. read more here.
Keywords: directing groups; ketones directing; sp3 fluorination; fluorination ... See more keywords
sp3 C–H activation via exo-type directing groups
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc04768a
Abstract: The application of exo-type directing groups (DGs) has led to the discovery of a wide range of novel C(sp3)–H activation methods, which allow efficient and site-selective functionalization of alcohol and amide derivatives. read more here.
Keywords: exo type; type directing; directing groups; sp3 activation ... See more keywords
Combining transition metals and transient directing groups for C–H functionalizations
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra03230k
Abstract: In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C–H bonds, transition… read more here.
Keywords: directing groups; transition metals; combining transition; metals transient ... See more keywords
Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc04676k
Abstract: Transition metal catalyzed C(sp3)–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a… read more here.
Keywords: distal sp3; directing groups; transition metal; diverse strategies ... See more keywords
Catalytic C-H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01414b
Abstract: Iridium-catalysed regioselective C-H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and… read more here.
Keywords: alkynylation benzylamines; directing groups; catalytic alkynylation; benzylamines aldehydes ... See more keywords
Thieme Chemistry Journals Awardees – Where Are They Now? New Reaction Mode in Carboxylate-Directed C–H Functionalizations: Carboxylates as Deciduous Directing Groups
Sign Up to like & getrecommendations! Published in 2017 at "Synlett"
DOI: 10.1055/s-0036-1588450
Abstract: The widely available carboxylate groups have recently emerged as advantageous leaving groups for regioselective ipso substitutions and directing groups for ortho-C–H functionalizations in transition-metal catalysis. In the latter reactions, they can subsequently be transformed into… read more here.
Keywords: directing groups; carboxylate; deciduous directing; chemistry ... See more keywords