Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Chem"
DOI: 10.1016/j.chempr.2017.11.002
Abstract: Summary The development of methods for the functionalization of otherwise inert C–H bonds is one of the major foci in molecular syntheses. Recent advances have significantly improved the arsenal of synthetic chemistry, enabling the use… read more here.
Keywords: directing groups; groups transformative; metal; transformative activation ... See more keywords
Synthesis of Polyamides Bearing Directing Groups and Their Catalytic Depolymerization.
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DOI: 10.1021/acs.orglett.4c04829
Abstract: We report a directing group (DG)-enabled strategy for polyamide depolymerization. Pyridine-based DGs selectively interact with In(III) catalysts, activating amide bonds for catalytic cleavage via alcoholysis. The process achieves efficient depolymerization of DG-introduced polyamides into recyclable… read more here.
Keywords: directing groups; bearing directing; synthesis polyamides; depolymerization ... See more keywords
Ketones as directing groups in photocatalytic sp3 C–H fluorination† †Electronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02703f
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc02703f
Abstract: Visible light-sensitization allows conformationally rigid ketones to act as “directing groups” for aliphatic fluorination using Selectfluor, catalytic benzil, and LEDs. read more here.
Keywords: directing groups; ketones directing; sp3 fluorination; fluorination ... See more keywords
sp3 C–H activation via exo-type directing groups
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc04768a
Abstract: The application of exo-type directing groups (DGs) has led to the discovery of a wide range of novel C(sp3)–H activation methods, which allow efficient and site-selective functionalization of alcohol and amide derivatives. read more here.
Keywords: exo type; type directing; directing groups; sp3 activation ... See more keywords
Combining transition metals and transient directing groups for C–H functionalizations
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DOI: 10.1039/c8ra03230k
Abstract: In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C–H bonds, transition… read more here.
Keywords: directing groups; transition metals; combining transition; metals transient ... See more keywords
Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations
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DOI: 10.1039/d0sc04676k
Abstract: Transition metal catalyzed C(sp3)–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a… read more here.
Keywords: distal sp3; directing groups; transition metal; diverse strategies ... See more keywords
Catalytic C-H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01414b
Abstract: Iridium-catalysed regioselective C-H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and… read more here.
Keywords: alkynylation benzylamines; directing groups; catalytic alkynylation; benzylamines aldehydes ... See more keywords
Enantioselective C-H bond functionalization under Co(III)-catalysis.
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DOI: 10.1039/d3cc05329f
Abstract: While progress in enantioselective C-H functionalization has been accomplished by employing 4d and 5d transition metal-based catalysts, the rapid depletion of these metals in the earth's crust poses a serious threat to making these protocols… read more here.
Keywords: directing groups; iii; bond functionalization; enantioselective bond ... See more keywords
Recent advances in asymmetric C–H bond functionalization enabled by chiral directing groups
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DOI: 10.1039/d5qo01354b
Abstract: Chiral directing groups (CDG) offer a streamlined approach to transition-metal-catalyzed asymmetric C–H activation for synthesizing diverse chiral scaffolds with central, planar, and axial chirality. read more here.
Keywords: directing groups; bond functionalization; chiral directing; recent advances ... See more keywords
Thieme Chemistry Journals Awardees – Where Are They Now? New Reaction Mode in Carboxylate-Directed C–H Functionalizations: Carboxylates as Deciduous Directing Groups
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DOI: 10.1055/s-0036-1588450
Abstract: The widely available carboxylate groups have recently emerged as advantageous leaving groups for regioselective ipso substitutions and directing groups for ortho-C–H functionalizations in transition-metal catalysis. In the latter reactions, they can subsequently be transformed into… read more here.
Keywords: directing groups; carboxylate; deciduous directing; chemistry ... See more keywords