Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0359-5
Abstract: Human liver cancers, including hepatocellular carcinomas and intra-hepatic cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding of cancer initiation could provide potential preventive therapies and increase survival. Models for studying human liver… read more here.
Keywords: initiation; cancer initiation; cancer; directly reprogrammed ... See more keywords
Metabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22073-7
Abstract: Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming… read more here.
Keywords: epithelial cells; mimcd cells; renal tubular; cells irecs ... See more keywords