MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114357
Abstract: Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations… read more here.
Keywords: directly targeting; biological pathways; pancreatic cancer; mirnas directly ... See more keywords
Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01312
Abstract: KRAS, the most frequently mutated oncogene, plays a predominant role in driving initiation and progression of cancers. Decades of effort to target KRAS using small molecules has been unsuccessful, causing KRAS to be considered an… read more here.
Keywords: directly targeting; inhibitors directly; small molecule; chemistry ... See more keywords
MicroRNA-144 silencing attenuates intimal hyperplasia by directly targeting PTEN
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2022.2123923
Abstract: ABSTRACT Background Intimal hyperplasia contributed by phenotypic switching of vascular smooth muscle cell (VSMC) plays an important role in the pathogenesis of various cardiovascular diseases. MicroRNA-144 (miR-144) is recently reported to be implicated in the… read more here.
Keywords: microrna 144; targeting pten; mir 144; intimal hyperplasia ... See more keywords
miR-663 promotes NPC cell proliferation by directly targeting CDKN2A.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7129
Abstract: MicroRNAs (miRs) act as important regulators during the development and progression of human cancer; however, the regulatory mechanism of miR-663 in nasopharyngeal carcinoma (NPC) remains unclear. The present study demonstrated that serum miR‑663 levels were… read more here.
Keywords: directly targeting; cdkn2a; c666 cells; proliferation ... See more keywords
miR-93 enhances cell proliferation by directly targeting CDKN1A in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7492
Abstract: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck with the highest incidence rate in southern China. The aim of the present study was to understand the molecular mechanisms that underlie the… read more here.
Keywords: directly targeting; cdkn1a; cell proliferation; mir ... See more keywords