Synthesis of Donor/Acceptor-Substituted Diazo Compounds in Flow and Their Application in Enantioselective Dirhodium-Catalyzed Cyclopropanation and C-H Functionalization.
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DOI: 10.1021/acs.orglett.7b01073
Abstract: A tandem reaction system has been developed for the preparation of donor/acceptor-substituted diazo compounds in continuous flow coupled to dirhodium-catalyzed C-H functionalization or cyclopropanation. Hydrazones were oxidized in flow by solid-supported N-iodo-p-toluenesulfonamide potassium salt (PS-SO2NIK)… read more here.
Keywords: diazo compounds; dirhodium catalyzed; substituted diazo; donor acceptor ... See more keywords
Dirhodium-Catalyzed Chemo- and Site-Selective C–H Amidation of N,N-Dialkylanilines
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DOI: 10.1055/a-1334-6450
Abstract: A method for dirhodium-catalyzed C(sp3)-H amidation of N,N-dimethylanilines was developed. Chemoselective C(sp3)-H amidation of N-methyl group proceeded exclusively in the presence of C(sp2)-H bonds of the electron-rich aromatic ring. Site-selective C(sp3)-H amidation proceeded exclusively at… read more here.
Keywords: site selective; sp3 amidation; amidation; dirhodium catalyzed ... See more keywords