Effect of Equatorial Ligand Substitution on the Reactivity with Proteins of Paddlewheel Diruthenium Complexes: Structural Studies
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.2c04103
Abstract: The paddlewheel [Ru2Cl(O2CCH3)4] complex was previously reported to react with the model protein hen egg white lysozyme (HEWL), forming adducts with two diruthenium moieties bound to Asp101 and Asp119 side chains upon the release of… read more here.
Keywords: reactivity proteins; paddlewheel diruthenium; effect equatorial; diruthenium ... See more keywords
Comparative Analysis of the Inhibitory Mechanism of Aβ1-42 Aggregation by Diruthenium Complexes.
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DOI: 10.1021/acs.inorgchem.4c01218
Abstract: There is a growing interest in the search for metal-based therapeutics for protein misfolding disorders such as Alzheimer's disease (AD). A novel and largely unexplored class of metallodrugs is constituted by paddlewheel diruthenium complexes, which… read more here.
Keywords: analysis inhibitory; diruthenium complexes; comparative analysis; aggregation ... See more keywords
Anthraquinone-bridged diruthenium(II) complexes inhibit migration and invasion of human hepatocarcinoma MHCC97-H cells
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DOI: 10.1039/c7qi00149e
Abstract: Metastasis is a major health threat for most cancer patients, thus anti-metastasis treatments that reduce cell migration and invasion are critical for cancer treatment. In this study, four anthraquinone-bridged diruthenium(II) complexes, [(bpy)2Ru(L)Ru(bpy)2]4+ (Ru1, L =… read more here.
Keywords: anthraquinone bridged; invasion; bis imidazo; diruthenium complexes ... See more keywords
Hammett-law Correlation in the Electron-donation Ability of trans-Heteroleptic Benzoate-bridged Paddlewheel-type Diruthenium(II,II) Complexes
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DOI: 10.1246/cl.180155
Abstract: A series of trans-heteroleptic paddlewheel-type diruthenium(II,II) complexes [Ru2(2,6-(CF3)2PhCO2)2(p-RPhCO2)2(THF)2] was synthesized by substituting para-R-substituted benzoate ligands (p-RPhCO2−, R = CF3, Cl, F, H, Ph, Me, MeO, OH) in [Ru2(p-RPhCO2)4(THF)2] with 2,6-bis(trifluoromethyl)benzoate (2,6-(CF3)2PhCO2−). The redox potential (E1/2)… read more here.
Keywords: diruthenium complexes; trans heteroleptic; paddlewheel type; type diruthenium ... See more keywords