Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0010
Abstract: Importance The value of serum neurofilament light chain (sNfL) levels for predicting long-term disability in patients with multiple sclerosis (MS) remains controversial. Objective To assess whether high sNfL values are associated with disability worsening in… read more here.
Keywords: disability worsening; disability; event; month ... See more keywords
Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.534
Abstract: To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial (n = 487;… read more here.
Keywords: progressive multiple; multiple sclerosis; disability worsening; primary progressive ... See more keywords
Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57172-3
Abstract: Exposure to per- and polyfluorinated substances (PFAS) and hydroxylated polychlorinated biphenyls (OH-PCBs) is associated with adverse human health effects, including immunosuppression. It is unknown if these substances can affect the course of autoimmune diseases. This… read more here.
Keywords: multiple sclerosis; risk; pcbs; disability worsening ... See more keywords
Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2180316
Abstract: ABSTRACT Predicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut… read more here.
Keywords: long term; disability worsening; term; multiple sclerosis ... See more keywords
#3380 The association between estimated glomerular filtration rate (eGFR) and disability worsening in patients with multiple sclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.1431
Abstract: Multiple sclerosis (MS) is a chronic autoimmune neurological disease characterized by focal demyelinated lesions of the central nervous system, leading to heterogenous neurological impairments. In recent years, emerging evidence suggests a complex interrelation between MS… read more here.
Keywords: worsening patients; edss score; baseline; disability worsening ... See more keywords
Predicting disability worsening in relapsing and progressive multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000000928
Abstract: Purpose of review Multiple sclerosis (MS) is a clinically heterogeneous disease, which complicates expectant management as well as treatment decisions. This review provides an overview of both well established and emerging predictors of disability worsening,… read more here.
Keywords: disability; relapsing progressive; multiple sclerosis; predicting disability ... See more keywords