Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
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DOI: 10.1158/2159-8290.cd-21-1661
Abstract: Mutational scanning in base-edited IDH-mutant leukemia cells uncovered recurrent mutations that disable uncompetitive inhibition, which reveals a new class of pathogenic mutations and mechanisms for resistance to IDH-targeting therapies. read more here.
Keywords: inhibition; disabling uncompetitive; uncompetitive inhibition; inhibition oncogenic ... See more keywords