Cellular Handling of Protein Aggregates by Disaggregation Machines.
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DOI: 10.1016/j.molcel.2018.01.004
Abstract: Both acute proteotoxic stresses that unfold proteins and expression of disease-causing mutant proteins that expose aggregation-prone regions can promote protein aggregation. Protein aggregates can interfere with cellular processes and deplete factors crucial for protein homeostasis.… read more here.
Keywords: protein; disaggregation; cellular handling; disaggregation machines ... See more keywords