Identification of Factors Associated With the Development of Optic Disc Edema During Spaceflight.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.4396
Abstract: Importance Approximately 70% of crew members who complete long-duration missions to the International Space Station develop signs of optic disc edema, a hallmark finding of spaceflight-associated neuro-ocular syndrome. The onset and magnitude of edema differ… read more here.
Keywords: cup; disc edema; edema; thickness ... See more keywords
3D‐Printed Negative Poisson's Ratio Composite Scaffolds with Antibacterial and Microenvironment Remodeling Capacities for Ameliorating Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202502365
Abstract: During the process of intervertebral disc degeneration (IDD), localized inflammatory responses occur, triggering an imbalance in the decomposition and metabolism of nucleus pulposus (NP) cells, which subsequently leads to the functional impairment of the intervertebral… read more here.
Keywords: disc degeneration; intervertebral disc; negative poisson; poisson ratio ... See more keywords
A One‐Stone‐Two–Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202411290
Abstract: Intervertebral disc degeneration (IVDD) is characterized by fibrosis of nucleus pulposus (NP) cells and accelerated surrounding extracellular matrix catabolism. Bioactive hydrogels have shown significant potential in regulating cellular functions and tissue homeostasis. In this work,… read more here.
Keywords: intervertebral disc; matrix; hydrogel; disc ... See more keywords
Bacterial nanocellulose: A versatile biopolymer production using a cost‐effective wooden disc based rotary reactor
Sign Up to like & getrecommendations! Published in 2024 at "Biopolymers"
DOI: 10.1002/bip.23577
Abstract: Bacterial nanocellulose (BNC) has various unique qualities, including high mechanical strength, crystallinity, and high water‐holding capacity, which makes it appropriate for a wide range of industrial applications. But its lower yield coupled with its high… read more here.
Keywords: bnc; yield; bacterial nanocellulose; wooden disc ... See more keywords
Relationship between degree of separation of endplate cartilage and severity of intervertebral disc herniation
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Anatomy"
DOI: 10.1002/ca.23816
Abstract: Degeneration of intervertebral disc and fissures in the anulus was caused by compression and distraction, which lead to nucleus pulposus herniation. However, controversy remains regarding the exact mechanism behind disc herniation. The aim of this… read more here.
Keywords: disc herniation; endplate cartilage; disc; herniation ... See more keywords
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11258
Abstract: Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from… read more here.
Keywords: disc; pi3k akt; intervertebral disc; nucleus pulposus ... See more keywords
Intervertebral Cervical Disc Intensity (IVCDI) Detection and Classification on MRI Scans Using Deep Learning Methods
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Imaging Systems and Technology"
DOI: 10.1002/ima.23174
Abstract: Radiologists manually interpret magnetic resonance imaging (MRI) scans for the detection of intervertebral cervical disc degeneration, which are often obtained in a primary care or emergency hospital context. The ability of computer models to work… read more here.
Keywords: deep learning; intensity; mri scans; intervertebral cervical ... See more keywords
Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13192
Abstract: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition (Myosteatosis). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral… read more here.
Keywords: magnetic resonance; resonance imaging; myosteatosis; disc degeneration ... See more keywords
Bioactive Silk Fibroin Hydrogel Harnesses BMSCs‐EVs to Modulate Inflammatory Microenvironment in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70159
Abstract: ABSTRACT Intervertebral disc degeneration (IVDD) is a common age‐related disorder associated with inflammation, pain and impaired mobility. In this study, we developed a therapeutic system using silk fibroin (SF) hydrogel loaded with mRNA‐engineered extracellular vesicles… read more here.
Keywords: disc degeneration; intervertebral disc; hydrogel; silk fibroin ... See more keywords
Spheroid-Derived BMSC Exosomes Enhance Proliferation and Matrix Remodeling of Nucleus Pulposus Cell Clusters in Degenerative Disc Repair.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202507073
Abstract: Current intervertebral disc degeneration (IDD) treatments mainly relieve symptoms but fail to enable biological repair. This study develops a clinical combination therapy involving autologous nucleus pulposus (NP) tissue fragments mixed with bone marrow aspirate (BMA)-enriched… read more here.
Keywords: matrix; nucleus pulposus; repair; cell clusters ... See more keywords
Water Transport‐Modulated Highly Compressive Hydrogel for Total Biomimetic Sensing Intervertebral Disc
Sign Up to like & getrecommendations! Published in 2025 at "Small Methods"
DOI: 10.1002/smtd.202500292
Abstract: Degenerative disc disease (DDD) affects millions globally, with artificial total disc replacement (A‐TDR) emerging as a key surgical intervention to restore spinal function and mobility. Current implantable prostheses incorporating multi‐component architectures to replicate the functional… read more here.
Keywords: water; transport modulated; water transport; disc ... See more keywords