Association between severe lumbar disc degeneration and self‐reported occupational physical loading
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Occupational Health"
DOI: 10.1002/1348-9585.12316
Abstract: Abstract Objectives Occupational physical loading has been reported to be associated with intervertebral disc degeneration. However, previous literature reports inconsistent results for different vertebral levels. The aim of our study was to investigate the association… read more here.
Keywords: physical loading; disc degeneration; loading; occupational physical ... See more keywords
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207216
Abstract: Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO) databases.… read more here.
Keywords: iron; disc degeneration; intervertebral disc; ferroptosis ... See more keywords
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11258
Abstract: Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from… read more here.
Keywords: disc; pi3k akt; intervertebral disc; nucleus pulposus ... See more keywords
Understanding embryonic development for cell‐based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.217
Abstract: Chronic low back and neck pain are associated with intervertebral disc degeneration and are major contributors to the global burden of disability. New evidence now suggests that disc degeneration comprises a spectrum of subphenotypes influenced… read more here.
Keywords: based therapies; degeneration; cell based; intervertebral disc ... See more keywords
Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29191
Abstract: It is previously suggested that insulin‐like growth factor binding proteins (IGFBPs) potentially share an association with disc degeneration (DD) that causes back pain. This study aimed at exploring the functional relevance of IGFBP5 in DD… read more here.
Keywords: erk mapk; proliferation; mapk axis; igfbp5 ... See more keywords
Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13192
Abstract: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition (Myosteatosis). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral… read more here.
Keywords: magnetic resonance; resonance imaging; myosteatosis; disc degeneration ... See more keywords
Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.24787
Abstract: Cartilage endplate (CEP) biochemical composition may influence disc degeneration and regeneration. However, evaluating CEP composition in patients remains a challenge. We used T2* mapping from ultrashort echo‐time (UTE) magnetic resonance imaging (MRI), which is sensitive… read more here.
Keywords: cep values; disc degeneration; degeneration; composition ... See more keywords
Disc cell therapy with bone-marrow-derived autologous mesenchymal stromal cells in a large porcine disc degeneration model
Sign Up to like & getrecommendations! Published in 2018 at "European Spine Journal"
DOI: 10.1007/s00586-018-5728-4
Abstract: AbstractPurposeDisc regeneration through matrix-assisted autologous mesenchymal stromal cell therapy seems promising against disc degeneration with convincing results in small animal models. Whether these positive results can be transferred to larger animal models or humans is… read more here.
Keywords: mesenchymal stromal; matrix; degeneration; cell ... See more keywords
ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2019 at "European Spine Journal"
DOI: 10.1007/s00586-019-05902-9
Abstract: PurposeChronic low back pain causes structural remodelling and inflammation in the multifidus muscle. Collagen expression is increased in the multifidus of humans with lumbar disc degeneration. However, the extent and mechanisms underlying the increased fibrotic… read more here.
Keywords: disc degeneration; physical activity; activity; multifidus muscle ... See more keywords
Association of vitamin D receptor gene polymorphisms with disc degeneration
Sign Up to like & getrecommendations! Published in 2019 at "European Spine Journal"
DOI: 10.1007/s00586-019-06215-7
Abstract: Purpose Numerous candidate genes and single-nucleotide polymorphisms (SNPs) have been identified in the background of lumbar disc degeneration (LDD). However, in most of these underpowered studies, definitions of LDD are inconsistent; moreover, many of the… read more here.
Keywords: vitamin receptor; gene polymorphisms; degeneration; association ... See more keywords
The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain
Sign Up to like & getrecommendations! Published in 2022 at "European Spine Journal"
DOI: 10.1007/s00586-022-07206-x
Abstract: The composition of the subchondral bone marrow and cartilage endplate (CEP) could affect intervertebral disc health by influencing vertebral perfusion and nutrient diffusion. However, the relative contributions of these factors to disc degeneration in patients… read more here.
Keywords: composition; bone marrow; disc degeneration; disc ... See more keywords