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   Articles with "disc1" as a keyword



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50‐kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats

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recommendations! Published in 2023 at "Brain and Behavior"

DOI: 10.1002/brb3.2984

Abstract: Patients diagnosed with neuropsychiatric disorders, such as autism and schizophrenia, suffer from disorganized speech. The disrupted‐in‐schizophrenia 1 (DISC1) protein pathway is considered a risk factor for the development of several psychiatric disorders and plays an… read more here.

Keywords: social anhedonia; ultrasonic vocalizations; transgenic disc1; rats khz ... See more keywords
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Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice

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recommendations! Published in 2018 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2017.10.039

Abstract: HIGHLIGHTSMaternal deprivation alters the basal levels of activity with the hippocampal subfields in mice.Maternal deprivation induces a state of spontaneous hyperactivity and impairs prepulse inhibition.Expression of a dominant negative form of Disc1 impairs cued and… read more here.

Keywords: maternal deprivation; pathology; disc1; activity ... See more keywords
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DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.11.043

Abstract: A wide range of Ca2+-mediated functions are enabled by the dynamic properties of Ca2+, all of which are dependent on the endoplasmic reticulum (ER) and mitochondria. Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that is… read more here.

Keywords: stress; ca2; mitochondria ca2; mam ... See more keywords
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Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2018.10.055

Abstract: D-Serine, an endogenous coagonist of N-methyl-d-aspartate receptors (NMDARs) at the glycine binding site, is synthesized by serine racemase (SR) through conversion of l-Serine. Dysregulation of SR/D-Serine and Disrupted-In-Schizophrenia-1 (DISC1) contributes to the pathogenesis of schizophrenia… read more here.

Keywords: serine racemase; serine; disc1 agglomerates; schizophrenia disc1 ... See more keywords
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Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation

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recommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"

DOI: 10.1016/j.pnpbp.2018.12.007

Abstract: &NA; Dopamine D2 receptor (D2R) hyperactivity causes altered brain development and later produces onset of symptoms mimicking schizophrenia. It is known that D2R interacts with disrupted in schizophrenia 1 (DISC1); however, the effect of D2R‐DISC1… read more here.

Keywords: hyperactivity; haloperidol; neurite lesions; disc1 ... See more keywords
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DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice

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recommendations! Published in 2017 at "Neuropsychopharmacology"

DOI: 10.1038/npp.2017.129

Abstract: The functional role of genetic variants in glia in the pathogenesis of psychiatric disorders remains poorly studied. Disrupted-In-Schizophrenia 1 (DISC1), a genetic risk factor implicated in major mental disorders, has been implicated in regulation of… read more here.

Keywords: mutant disc1; disc1 astrocytes; disc1; adult neurogenesis ... See more keywords
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Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1

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recommendations! Published in 2021 at "Translational Psychiatry"

DOI: 10.1038/s41398-021-01212-1

Abstract: Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that has been implicated in multiple mental disorders. DISC1 is known to regulate neuronal proliferation, signaling, and intracellular calcium homeostasis, as well as neurodevelopment. Although DISC1 was linked… read more here.

Keywords: bmal1; disc1; disrupted schizophrenia; circadian rhythm ... See more keywords
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The natural Disc1-deletion present in several inbred mouse strains does not affect sleep

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-06015-3

Abstract: The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for… read more here.

Keywords: disc1 deletion; deletion; mice; natural disc1 ... See more keywords
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The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]‐DOPA PET study

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recommendations! Published in 2018 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddy242

Abstract: Abstract Whilst the role of the Disrupted‐in‐Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its function lends it credibility as a candidate. A key aspect of this… read more here.

Keywords: synthesis capacity; dopamine synthesis; disc1; synthesis ... See more keywords
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F201. KINASE NETWORK DYSREGULATION IN SCHIZOPHRENIA: IMPLICATIONS FOR NEW TREATMENT STRATEGIES

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recommendations! Published in 2018 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sby017.732

Abstract: Abstract Background Disrupted-in-schizophrenia 1 (DISC1) is one of the most substantiated genetic risk factors for schizophrenia (SZ). A large array of animal studies supports an etiopathogenic role of DISC1, by linking it with regulation of… read more here.

Keywords: cell line; kinase; kinase network; disc1 ... See more keywords
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The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves’ disease in the Chinese population

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recommendations! Published in 2022 at "Medicine"

DOI: 10.1097/md.0000000000031501

Abstract: Previously, a case series study was conducted on our part in which 5 patients with Graves’ disease (GD) were collected from a 3-generation family to screen for susceptibility genes responsible for GD. The single nucleotide… read more here.

Keywords: graves disease; group; traf3ip3 disc1; disc1 ... See more keywords