Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14522
Abstract: The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen… read more here.
Keywords: discoidin domain; domain receptor; erbb3 signaling; receptor ... See more keywords
Special issue “The advance of solid tumor research in China”: Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34227
Abstract: Tumor metastasis is one of the main reasons for the high mortality rate associated with colorectal cancer (CRC). However, its underlying mechanisms have not been fully understood. Here, we reported that the expression of discoidin… read more here.
Keywords: metastasis; discoidin domain; crc; colorectal cancer ... See more keywords
DDR2, a discoidin domain receptor, is a marker of periosteal osteoblast and osteoblast progenitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01108-y
Abstract: The periosteum has a bilayered structure that surrounds cortical bone. The outer layer is rich in connective tissue and fibroblasts, while the inner layer in contact with the cortical surface of the bone predominantly consists… read more here.
Keywords: osteoblast progenitors; bone; ddr2; periosteum ... See more keywords
Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103162
Abstract: Background Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by collagens that is involved in the pathogenesis of fibrotic disorders. Interestingly, de novo production of the collagen type I (Col… read more here.
Keywords: alport syndrome; receptor; discoidin domain; domain receptor ... See more keywords
Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer1
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.02.003
Abstract: Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated… read more here.
Keywords: ddr1; gastric cancer; metastasis; ddr1 silenced ... See more keywords
DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1618540
Abstract: ABSTRACT Therapy resistance of tumor cells is a major obstacle for efficient anticancer treatment approaches and has been attributed to tumor heterogeneity as well as genetic and epigenetic changes. Accumulating evidence demonstrates that tumor cell… read more here.
Keywords: kinase; ddr1 discoidin; resistance; receptor ... See more keywords
Control of craniofacial development by the collagen receptor, discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.03.479017
Abstract: Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in discoidin domain receptor 2 (DDR2), a non-integrin collagen receptor,… read more here.
Keywords: discoidin domain; domain receptor; development; collagen ... See more keywords
Abstract 5010: Inhibition of discoidin domain receptor 1 (DDR1) as a new therapeutic strategy for osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5010
Abstract: Osteosarcoma is the most common type of bone cancer. Current management for osteosarcoma includes neoadjuvant chemotherapy and surgery. Unfortunately, some patients eventually develop recurrent or metastatic diseases and treatment options are extremely limited. Discoidin domain… read more here.
Keywords: inhibition; osteosarcoma; discoidin domain; ddr1 ... See more keywords
Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Dental Research"
DOI: 10.1177/0022034519881136
Abstract: The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues,… read more here.
Keywords: ddr1; histology; bone; ddr1 versus ... See more keywords
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00388-y
Abstract: Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor… read more here.
Keywords: wound healing; c1q; ddr2; domain receptor ... See more keywords
Focusing on discoidin domain receptors in premalignant and malignant liver diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1123638
Abstract: Discoidin domain receptors (DDRs) are receptor tyrosine kinases on the membrane surface that bind to extracellular collagens, but they are rarely expressed in normal liver tissues. Recent studies have demonstrated that DDRs participate in and… read more here.
Keywords: discoidin domain; liver; premalignant malignant; malignant liver ... See more keywords