Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents.
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DOI: 10.1016/j.ejmech.2020.112349
Abstract: In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity… read more here.
Keywords: high efficiency; gastric cancer; lead optimization; discover high ... See more keywords