E3 Ligases Meet Their Match: Fragment-Based Approaches to Discover New E3 Ligands and to Unravel E3 Biology
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01882
Abstract: Ubiquitination is a key post-translational modification of proteins, affecting the regulation of multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called E3 ubiquitin ligases, responsible for directing the covalent attachment of ubiquitin… read more here.
Keywords: fragment based; discover new; new ligands; ligases meet ... See more keywords
Mining the bacterial genome to discover new antimicrobial molecules
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202115409
Abstract: Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics… read more here.
Keywords: bacterial genome; genome discover; medicine; mining bacterial ... See more keywords
Travel intention of Brazilian students : are they ready to discover new places and things?
Sign Up to like & getrecommendations! Published in 2017 at "Tourism Analysis"
DOI: 10.3727/108354217x15023805452031
Abstract: This article explores the holiday motives of Brazilian student travelers. It tests whether relaxation, feel-good experience, and socialization impact their preferences to link with natural experiences and therefore provide them with reasons to travel. The… read more here.
Keywords: new places; discover new; natural experience; places things ... See more keywords