A Materials Acceleration Platform for Organic Laser Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207070
Abstract: Conventional materials discovery is a laborious and time‐consuming process that can take decades from initial conception of the material to commercialization. Recent developments in materials acceleration platforms promise to accelerate materials discovery using automation of… read more here.
Keywords: acceleration platform; organic laser; materials acceleration; discovery ... See more keywords
Perimortem versus postmortem damage: The recent case of Cioclovina 1.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of physical anthropology"
DOI: 10.1002/ajpa.24045
Abstract: OBJECTIVES Kranioti, Grigorescu, and Harvati have recently described (PLoS One 2019, 14(7),e0216718) the breakage to the Cioclovina 1 earlier Upper Paleolithic cranium as indicating fatal interhuman blunt trauma. We have reassessed their analysis in terms… read more here.
Keywords: cioclovina; versus postmortem; discovery; damage ... See more keywords
Optimizing depth and type of high‐throughput sequencing data for microsatellite discovery
Sign Up to like & getrecommendations! Published in 2019 at "Applications in Plant Sciences"
DOI: 10.1002/aps3.11298
Abstract: Premise Simple sequence repeat (SSR) markers (microsatellites) are a mainstay of many labs, especially when working on a limited budget, carrying out preliminary analyses, and in teaching. Whether SSRs mined from plant genomes or transcriptomes… read more here.
Keywords: optimizing depth; sequencing data; discovery; throughput sequencing ... See more keywords
Lessons in Organic Fluorescent Probe Discovery
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100171
Abstract: Fluorescent probes have gained profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of fluorophores into fluorescent probes continues to be a robust field for… read more here.
Keywords: discovery; probe discovery; fluorescent probe; lessons organic ... See more keywords
Statistical Analysis and Discovery of Heterogeneous Catalysts Based on Machine Learning from Diverse Published Data
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900971
Abstract: The literature provides insights for catalyst design and discovery. Effective analysis of reported data using machine learning (ML) methods offers the ability to gain valuable information. However, utilizing the literature in this way has obstacles… read more here.
Keywords: machine learning; analysis; published data; discovery ... See more keywords
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700786
Abstract: Protozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery… read more here.
Keywords: library triazole; triazole linked; focused library; phenotypic ... See more keywords
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000024
Abstract: Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one‐step syntheses are a powerful approach for the fast discovery of novel bioactive molecules. Here, we are presenting a pipeline for… read more here.
Keywords: discovery aspartyl; discovery; aspartyl protease; protease inhibitors ... See more keywords
Discovery of Anti‐tubercular Analogues of Bedaquiline with Modified A‐, B‐ and C‐Ring Subunits
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200533
Abstract: To date, the clinical use of the anti‐tubercular therapy bedaquiline has been somewhat limited due to safety concerns. Recent investigations determined that modification of the B‐ and C‐ring units of bedaquiline delivered new diarylquinolines (for… read more here.
Keywords: anti tubercular; tubercular activity; ring units; within bedaquiline ... See more keywords
Discovery of over 200 new and expanded genetic conditions using GeneMatcher
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24351
Abstract: GeneMatcher is a platform through which various stakeholders can connect with others interested in candidate gene findings. GeneDx, a diagnostic laboratory, has utilized GeneMatcher over the last seven years to successfully facilitate connections between clinicians… read more here.
Keywords: expanded genetic; 200 new; new expanded; genematcher ... See more keywords
Genomics4RD: An integrated platform to share Canadian deep‐phenotype and multiomic data for international rare disease gene discovery
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24354
Abstract: Despite recent progress in the understanding of the genetic etiologies of rare diseases (RDs), a significant number remain intractable to diagnostic and discovery efforts. Broad data collection and sharing of information among RD researchers is… read more here.
Keywords: genomics4rd integrated; discovery; multiomic data; platform share ... See more keywords
Opportunities for pharmacoproteomics in biomarker discovery
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200031
Abstract: Proteomic data are a uniquely valuable resource for drug response prediction and biomarker discovery because most drugs interact directly with proteins in target cells rather than with DNA or RNA. Recent advances in mass spectrometry… read more here.
Keywords: pharmacoproteomics biomarker; biomarker discovery; drug; discovery ... See more keywords