Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02197
Abstract: Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) pathway, is were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular potency, along with computational,… read more here.
Keywords: interferon genes; stimulator interferon; discovery 1454; cyclic dinucleotide ... See more keywords