Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.
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DOI: 10.1021/acsmedchemlett.8b00213
Abstract: GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets and enteroendocrine L-cells, and, when activated, elicits increased insulin secretion only in the presence of elevated glucose levels. We recently reported the discovery of… read more here.
Keywords: gpr40; discovery 6226; full agonist; gpr40 full ... See more keywords