Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials.
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DOI: 10.1021/acsmedchemlett.1c00663
Abstract: Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration. All four stereoisomers of this structure were synthesized,… read more here.
Keywords: carboline; discovery aminoalkyl; aminoalkyl carboline; box inspired ... See more keywords