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   Articles with "discovery antimicrobial" as a keyword



Discovery of Antimicrobial Lysins from the “Dark Matter” of Uncharacterized Phages Using Artificial Intelligence (Adv. Sci. 32/2024)

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202470193

Abstract: Antibacterial Proteins DeepLysin is the first unified software that employs artificial intelligence to mine novel antibacterial proteins from the ‘dark matter’. The best‐in‐class antibacterial protein LLysSA9 is identified, which can effectively kill drug‐resistant bacteria in… read more here.

Keywords: discovery antimicrobial; dark matter; artificial intelligence; antibacterial proteins ... See more keywords

Discovery of antimicrobial activity in chemical extracts derived from unexplored algal-bacterial culture systems and isolates

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-82056-9

Abstract: Global health is affected by viral, bacterial, and fungal infections that cause chronic and often fatal diseases. Identifying novel antimicrobials through innovative methods that are active against human pathogens will create a new, necessary pipeline… read more here.

Keywords: chemical; chemical extracts; algal bacterial; culture ... See more keywords

Discovery of antimicrobial peptides with notable antibacterial potency by an LLM-based foundation model.

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recommendations! Published in 2025 at "Science advances"

DOI: 10.1126/sciadv.ads8932

Abstract: Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Designer, an LLM-based approach, for swiftly designing antimicrobial peptides (AMPs) with desired… read more here.

Keywords: llm based; foundation; amp designer; antimicrobial peptides ... See more keywords

Rational Discovery of Antimicrobial Peptides by Means of Artificial Intelligence

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recommendations! Published in 2022 at "Membranes"

DOI: 10.3390/membranes12070708

Abstract: Antibiotic resistance is a worldwide public health problem due to the costs and mortality rates it generates. However, the large pharmaceutical industries have stopped searching for new antibiotics because of their low profitability, given the… read more here.

Keywords: rational discovery; antimicrobial peptides; artificial intelligence; discovery antimicrobial ... See more keywords

Rapid Discovery of Antimicrobial and Antimalarial Agents from Natural Product Fragments

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recommendations! Published in 2024 at "Separations"

DOI: 10.3390/separations11070194

Abstract: Fragment-based drug discovery (FBDD) focuses on small compounds, known as fragments, typically with a molecular weight of less than 300 Da. This study highlights the benefits of employing a pure natural product library for FBDD,… read more here.

Keywords: product fragments; product; natural product; antimicrobial antimalarial ... See more keywords