Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
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DOI: 10.1021/acs.jmedchem.1c00434
Abstract: Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the molecules, including… read more here.
Keywords: discovery azd8154; azd8154 dual; discovery; dual pi3k ... See more keywords