Discovery and biological evaluation of darolutamide derivatives as inhibitors and down-regulators of wild-type AR and the mutants.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111608
Abstract: Androgen receptor (AR) has been a target of prostate cancer (PC) for nearly six decades. Recently, downregulating or degrading AR and the mutants especially the splice variant 7 (AR-V7) lacking ligand binding domain (LBD) emerged… read more here.
Keywords: evaluation darolutamide; darolutamide; biological evaluation; darolutamide derivatives ... See more keywords
Discovery and biological evaluation of an adamantyl-amide derivative with likely MmpL3 inhibitory activity.
Sign Up to like & getrecommendations! Published in 2023 at "Tuberculosis"
DOI: 10.2139/ssrn.4282964
Abstract: A series of molecules containing bulky lipophilic scaffolds was screened for activity against Mycobacterium tuberculosis and a number of compounds with antimycobacterial activity were identified. The most active compound, (2E)-N-(adamantan-1-yl)-3-phenylprop-2-enamide (C1), has a low micromolar… read more here.
Keywords: discovery biological; biological evaluation; evaluation adamantyl; adamantyl amide ... See more keywords
Polyphenols as New Leads in Drug Discovery: Biological Activity and Mechanisms.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/138161282419180924094610
Abstract: Polyphenol-rich natural products have been associated to protective activities towards several chronic diseases. The exploitation of polyphenols as sources of molecules with nutraceutical/pharmacological interest depends on effective methods for compounds extraction to be further tested… read more here.
Keywords: biological activity; leads drug; polyphenols new; discovery biological ... See more keywords