Discovery and Biosynthesis of Antimicrobial Phenethylamine Alkaloids from the Marine Flavobacterium Tenacibaculum discolor sv11.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01173
Abstract: The bacterial genus Tenacibaculum has been associated with various ecological roles in marine environments. Members of this genus can act, for example, as pathogens, predators, or episymbionts. However, natural products produced by these bacteria are… read more here.
Keywords: phenethylamine; tenacibaculum; tenacibaculum discolor; discolor sv11 ... See more keywords
Discovery and Biosynthesis of Glycosylated Cycloheximide from a Millipede-Associated Actinomycete.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00951
Abstract: Chemical redundancy of microbial natural products (NPs) underscores the importance to exploit new resources of microorganisms. Insect-associated microbes are prolific but largely underexplored sources of diverse NPs. Herein, we discovered the new compound α-l-rhamnosyl-actiphenol (1)… read more here.
Keywords: discovery biosynthesis; glycosylated cycloheximide; millipede associated; cycloheximide ... See more keywords
Discovery and Biosynthesis of Ascorbylated Securinega Alkaloids
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DOI: 10.1021/acscatal.1c01514.s001
Abstract: Securinega alkaloids represent a class of plant secondary metabolites with intriguing bridged tetracyclic structures and promising biological activities. Despite extensive synthetic efforts and a number of innovative total syntheses, no relevant biosynthetic genes have been… read more here.
Keywords: securinega alkaloids; biosynthesis ascorbylated; discovery biosynthesis; study ... See more keywords
Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00074
Abstract: The design of small molecules that inhibit disease-relevant proteins represents a longstanding challenge of medicinal chemistry. Here, we describe an approach for encoding this challenge-the inhibition of a human drug target-into a microbial host and… read more here.
Keywords: active natural; natural products; discovery; biologically active ... See more keywords