Discovery of the Biosynthetic Machinery for the Stravidins, Biotin Antimetabolites.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00890
Abstract: Stravidins are peptide antibiotics produced by Streptomyces spp. Their antibacterial activity derives from an unusual amiclenomycin monomer, the warhead that inhibits biotin biosynthesis. Despite being discovered over five decades ago, stravidin biosynthesis has remained a… read more here.
Keywords: machinery; biosynthetic machinery; biotin antimetabolites; stravidins biotin ... See more keywords
The use of nitrogen-15 in microbial natural product discovery and biosynthetic characterization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1174591
Abstract: This mini-review covers the use of nitrogen-15 in bacterial and fungal natural product discovery and biosynthetic characterization from 1970 to 2022. Nitrogen is an important element in a number of bioactive and structurally intriguing natural… read more here.
Keywords: use nitrogen; product discovery; discovery biosynthetic; natural product ... See more keywords