Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.
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DOI: 10.1021/acs.jmedchem.1c02078
Abstract: Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors.… read more here.
Keywords: gcs; glucosylceramide synthase; discovery brain; brain penetrant ... See more keywords