Where is the Future of Drug Discovery for Cancer?
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.01.032
Abstract: With both small molecules and biologics succeeding in trials and in the clinic, the scope of drug discovery in cancer is changing. We asked a group of researchers to share their visions for how to… read more here.
Keywords: drug discovery; discovery cancer; future drug;
Abstract 4962: Discovery of cancer-specific E3 ligase ligands for targeted protein degradation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4962
Abstract: F-box/WD repeat-containing protein 7 (FBXW7) is the substrate recognition component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXW7 recognizes and binds phosphor-degrons within… read more here.
Keywords: discovery cancer; targeted protein; ligase; protein degradation ... See more keywords
Cancer Grand Challenges: Embarking on a New Era of Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1657
Abstract: Cancer Grand Challenges is a unique funding platform that dares global, multidisciplinary teams of researchers to come together, think differently, and tackle some of the toughest challenges in cancer research. Here, we discuss the nine… read more here.
Keywords: discovery cancer; grand challenges; cancer grand; cancer ... See more keywords