Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.
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DOI: 10.1016/j.ejmech.2021.113417
Abstract: NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these,… read more here.
Keywords: inflammasome inhibitors; analogues novel; inflammation; discovery chalcone ... See more keywords