Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
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DOI: 10.1021/acs.jmedchem.1c01436
Abstract: Interleukin-17 (IL-17) is a proinflammatory cytokine that plays a dominant role in inflammation, autoimmunity, and host defense. RORγt is a key transcription factor mediating T helper 17 (Th17) cell differentiation and IL-17 production, which is… read more here.
Keywords: sulfonamide derivative; chromane sulfonamide; derivative potent; compound ... See more keywords