A 2025 perspective on the role of machine learning for biomarker discovery in clinical proteomics
Sign Up to like & getrecommendations! Published in 2025 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2025.2545828
Abstract: ABSTRACT Introduction Machine learning holds significant promise for accelerating biomarker discovery in clinical proteomics, yet its real-world impact remains limited by widespread methodological pitfalls and unrealistic expectations. Areas covered In this perspective, we critically examine… read more here.
Keywords: clinical proteomics; discovery clinical; machine; machine learning ... See more keywords
Abstract 5504: Integrating ultrahigh-plex spatial phenotyping: From discovery to clinical applications
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5504
Abstract: Background The journey from discovering predictive spatial biomarkers (known as spatial signatures) for immunotherapy responses to their clinical application necessitates a cohesive approach bridging ultrahigh-plex discovery experiments with high-throughput translational studies. This study focuses on… read more here.
Keywords: ultrahigh plex; discovery clinical; analysis; spatial phenotyping ... See more keywords
Diagnostic Biomarkers: Are We Moving from Discovery to Clinical Application?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical chemistry"
DOI: 10.1373/clinchem.2018.292854
Abstract: BACKGROUND Despite considerable research investment, moving from biomarker discovery to clinical application has presented unique challenges. We aimed to evaluate progress toward clinical application of a sample of molecular- and "omics"-based diagnostic tests over a… read more here.
Keywords: discovery clinical; application; progress toward; toward clinical ... See more keywords
Biomaterials for Neurotherapeutics: From Lab Discovery to Clinical Application.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x1912211213141930
Abstract: read more here.
Keywords: lab discovery; clinical application; biomaterials neurotherapeutics; discovery clinical ... See more keywords
Biomarkers in ALS trials: from discovery to clinical utility
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2025.1636303
Abstract: Introduction Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disorder characterized by motor neuron degeneration, leading to muscle weakness, paralysis, and eventual respiratory failure. Despite advances in understanding… read more here.
Keywords: disease; discovery clinical; trial; biomarkers als ... See more keywords
COVID-19: An Update about the Discovery Clinical Trial
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13050098
Abstract: Finding efficacious and safe treatments for COVID-19 emerges as a crucial need in order to control the spread of the pandemic. Whereas plasma therapy attracts much interest, the European project Discovery focuses on the potentialities… read more here.
Keywords: covid update; clinical trial; discovery clinical; discovery ... See more keywords
Using telephony data to facilitate discovery of clinical workflows
Sign Up to like & getrecommendations! Published in 2017 at "Applied clinical informatics"
DOI: 10.4338/aci-2016-11-ra-0191
Abstract: BACKGROUND Discovery of clinical workflows to target for redesign using methods such as Lean and Six Sigma is difficult. VoIP telephone call pattern analysis may complement direct observation and EMR-based tools in understanding clinical workflows at… read more here.
Keywords: clinical workflows; discovery clinical; call; call patterns ... See more keywords