Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma.
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DOI: 10.1021/acs.jmedchem.3c00094
Abstract: Mutations in NRAS promote tumorigenesis and drug resistance. As this protein is often considered an undruggable target, it is urgent to develop novel strategies to suppress NRAS for anticancer therapy. Recent reports indicated that a… read more here.
Keywords: discovery clinically; mutant melanoma; nras mutant; nras repressor ... See more keywords