Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113933
Abstract: The P2Y14 nucleotide receptor, a subtype of P2Y receptors, is implicated in many human inflammatory diseases. Based on the identification of favorable residues of two screening hits in the almost symmetrical P2Y14 binding domain, we… read more here.
Keywords: benzoxazole acetamide; p2y14r antagonists; computational studies; phenyl benzoxazole ... See more keywords
Designing the Future of Biosensing: Advances in Aptamer Discovery, Computational Modeling, and Diagnostic Applications
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DOI: 10.3390/bios15100637
Abstract: Recent advances in computational tools, particularly machine learning (ML), deep learning (DL), and structure-based modeling, are transforming aptamer research by accelerating discovery and enhancing biosensor development. This review synthesizes progress in predictive algorithms that model… read more here.
Keywords: discovery computational; future biosensing; designing future; biosensing advances ... See more keywords
Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24081465
Abstract: Zika virus (ZIKV), one of the flaviviruses, has attracted worldwide attention since its large epidemics around Brazil. Association of ZIKV infection with microcephaly and neurological problems such as Guillain–Barré syndrome has prompted intensive pathological investigations.… read more here.
Keywords: computational analyses; analyses novel; novel small; zika virus ... See more keywords