Developments in the discovery and design of intranasal antidepressants
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DOI: 10.1080/17460441.2020.1776697
Abstract: ABSTRACT Introduction Depression remains a major cause of morbidity worldwide; consequently, there is a need in neuropsychiatry for new antidepressants with a rapid onset of action. Intranasal administration of antidepressants is an attractive and promising… read more here.
Keywords: discovery design; design intranasal; intranasal; intranasal antidepressants ... See more keywords
The discovery and design of novel HIV-1 capsid modulators and future perspectives
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DOI: 10.1080/17460441.2023.2157401
Abstract: ABSTRACT Introduction Although combination antiretroviral therapy (cART) has achieved significant success in treating HIV, the emergence of multidrug-resistant viruses and cumulative medication toxicity make it necessary to find new classes of antiretroviral agents with novel… read more here.
Keywords: hiv capsid; design; discovery design; hiv ... See more keywords
Discovery and design of G protein-coupled receptor targeting antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2193389
Abstract: ABSTRACT Introduction G protein-coupled receptors (GPCRs) are the target of one-third of all approved drugs; however, these drugs only target about one-eighth of the human repertoire of GPCRs. GPCRs regulate a diverse range of critical… read more here.
Keywords: discovery design; design protein; receptor; protein coupled ... See more keywords
Discovery and design of self-assembling peptides
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DOI: 10.1098/rsfs.2017.0028
Abstract: Peptides are ubiquitous in nature and useful in many fields, from agriculture as pesticides, in medicine as antibacterial and antifungal drugs founded in the innate immune systems, to medicinal chemistry as hormones. However, the concept… read more here.
Keywords: discovery design; medicine; assembling peptides; self assembling ... See more keywords
Neural Networks for Drug Discovery and Design
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DOI: 10.1145/3579634
Abstract: Architectures suited for molecules streamline the identification of pharmaceutical candidates. read more here.
Keywords: drug discovery; networks drug; neural networks; discovery design ... See more keywords
Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.618730
Abstract: Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural… read more here.
Keywords: discovery design; asperphenamate analogs; amino acid; design novel ... See more keywords