Drug Discovery and Development on Pma1, Where Are We Now? A Critical Review from 1995 to 2022
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200356
Abstract: Plasma membrane H+‐ATPase (Pma1) is an enzyme uniquely found in plants and fungi. The enzyme controls the nutrient uptake of plants and fungi via an electrochemical gradient processes, which is essential for their survival. Inhibiting… read more here.
Keywords: review; drug discovery; 1995 2022; discovery development ... See more keywords
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2627
Abstract: Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent advances in research on membrane transporters that are… read more here.
Keywords: discovery development; drug discovery; transporter; membrane transporters ... See more keywords
An Overview of Zebrafish Modeling Methods in Drug Discovery and Development.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_684
Abstract: Animal studies are recognized as a significant step forward in the bridging between drug discovery and clinical applications. Animal models, due to their relative genetic, molecular, physiological, and even anatomical similarities to humans, can provide… read more here.
Keywords: discovery development; modeling methods; drug discovery; drug ... See more keywords
Advancing Drug Discovery and Development Using Molecular Imaging (ADDMI): an Interest Group of the World Molecular Imaging Society and an Inaugural Session on Positron Emission Tomography (PET)
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1085-7
Abstract: Multi-modality molecular imaging techniques have expanded the role of imaging biomarkers in the pharmaceutical industry and are beginning to streamline the drug discovery and development process. The World Molecular Imaging Society (WMIS) serves as a… read more here.
Keywords: drug discovery; discovery development; molecular imaging;
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.02.011
Abstract: The use of phenotypic screening was central to the discovery and development of novel thalidomide analogs, the IMiDs (immunomodulatory drugs) agents. With the discovery that these agents bind the E3 ligase, CRL4CRBN, and alter its… read more here.
Keywords: discovery development; phenotypic screening; discovery; screening target ... See more keywords
Integrating in vitro disease models of the neurovascular unit into discovery and development of neurotherapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2021.100341
Abstract: The blood-brain barrier (BBB) regulates the transport of small molecules, proteins, and cells between the bloodstream and the central nervous system (CNS). Brain microvascular endothelial cells work with other resident brain cell types, including pericytes,… read more here.
Keywords: discovery development; disease; discovery; brain ... See more keywords
Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2018.11.002
Abstract: Over the past few decades, monoclonal antibodies (mAbs) have become one of the most important and fastest growing classes of therapeutic molecules, with applications in a wide variety of disease areas. As such, understanding of… read more here.
Keywords: discovery development; physiologically based; drug; drug discovery ... See more keywords
AI-based language models powering drug discovery and development.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.06.009
Abstract: The discovery and development of new medicines is expensive, time-consuming, and often inefficient, with many failures along the way. Powered by artificial intelligence (AI), language models (LMs) have changed the landscape of natural language processing… read more here.
Keywords: discovery development; discovery; drug discovery; language ... See more keywords
Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111710
Abstract: Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20-30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as… read more here.
Keywords: development extreme; discovery development; flt3; extreme selective ... See more keywords
Discovery and development of plasma kallikrein inhibitors for multiple diseases.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112137
Abstract: Plasma kallikrein (PKal) belongs to the family of trypsin-like serine proteases. The expression of PKal is associated with multiple physiological systems or pathways such as coagulation pathway, platelet aggregation process, kallikrein-kinin system, renin-angiotensin system and… read more here.
Keywords: kallikrein; discovery development; pkal inhibitors; plasma kallikrein ... See more keywords
Liquid crystalline polymers: Discovery, development, and the future
Sign Up to like & getrecommendations! Published in 2020 at "Polymer"
DOI: 10.1016/j.polymer.2020.122740
Abstract: Abstract Liquid crystalline polymers (LCPs) have drawn much interest because of their superior properties and widespread applications in high-performance polymer fibers, optics, energy storage, shape memory, surface modification, data storage, actuator, etc. LCPs can self-assemble… read more here.
Keywords: chain; discovery development; liquid crystalline; crystalline ... See more keywords