A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.021
Abstract: Human 15-lipoxygenase-1 (15-LOX-1) is a mammalian lipoxygenase which plays an important regulatory role in several CNS and inflammatory lung diseases. To further explore the role of this enzyme in drug discovery, novel potent inhibitors with… read more here.
Keywords: discovery drug; chemistry; drug; approach discovery ... See more keywords
Emerging target discovery and drug repurposing opportunities in chordoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1009193
Abstract: The development of effective and personalized treatment options for patients with rare cancers like chordoma is hampered by numerous challenges. Biomarker-guided repurposing of therapies approved in other indications remains the fastest path to redefining the… read more here.
Keywords: oncology; emerging target; chordoma; discovery drug ... See more keywords