Discovery of Efrotomycin Congeners and Heterologous Expression-Based Insights into the Self-Resistance Mechanism.
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DOI: 10.1021/acs.jnatprod.2c00986
Abstract: Four new efrotomycins, A1-A4 (1-4), were isolated from the salt mine-derived Amycolatopsis cihanbeyliensis DSM 45679 and structurally determined. Efrotomycins A3 (3) and A4 (4) feature a tetrahydrofuran ring configured distinctly from known elfamycins. Heterologous expression… read more here.
Keywords: discovery efrotomycin; self resistance; heterologous expression; efrotomycin congeners ... See more keywords