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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03380
Abstract: Through targeted high-throughput experimentation (HTE), we have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chemistry. AdBippyPhos is particularly effective for the…
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Keywords:
discovery evaluation;
throughput;
evaluation general;
method ... See more keywords
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Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00660
Abstract: RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into the 47S ribosomal RNA (rRNA) precursor. Further processing produces the 28S, 5.8S, and 18S rRNAs that are assembled into mature ribosomes. Many cancers exhibit higher…
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Keywords:
polymerase;
evaluation novel;
rna polymerase;
novel angular ... See more keywords