Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor.
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DOI: 10.1021/acsmedchemlett.9b00027
Abstract: The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herein, we report the… read more here.
Keywords: tbk1 inhibitor; highly selective; discovery gsk8612; tbk1 ... See more keywords