Discovery of hidden allosteric sites as novel targets for allosteric drug design.
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DOI: 10.1016/j.drudis.2017.10.001
Abstract: Hidden allosteric sites, as a novel type of allosteric site, are invisible in ligand-unbound (apo) crystal structures, but can emerge in ligand-bound (holo) crystal structures when a specific ligand binds to, and stabilizes, a unique… read more here.
Keywords: sites novel; allosteric sites; discovery hidden; drug ... See more keywords
T-pattern detection and analysis for the discovery of hidden features of behaviour
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2018.06.013
Abstract: BACKGROUND The behaviour of all living beings consists of hidden patterns in time; consequently, its nature and its underlying dynamics are intrinsically difficult to be perceived and detected by the unaided observer. METHOD Such a… read more here.
Keywords: detection; pattern detection; analysis; discovery hidden ... See more keywords