Discovery of a Highly Active Catalyst for Hydrogenolysis of C−O Bonds via Systematic, Multi‐metallic Catalyst Screening
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900462
Abstract: Hydrogenolysis of C−O bonds is a highly challenging reaction with the most efficient catalysts based on bimetallic assemblies. Systematic studies to identify the optimum metal combination have not been performed and, therefore, we designed a… read more here.
Keywords: multi metallic; discovery highly; highly active; hydrogenolysis ... See more keywords
Discovery of a highly variable bug killing fly species, Clytiomya continua (Diptera: Tachinidae: Phasiinae), in Korea with discussion on its systematic status
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2021.02.008
Abstract: Abstract At present, the genus Clytiomya of the tribe Gymnosomatini includes four Palaearctic species, which exhibit high intraspecific variability. While studying Korean members of the bug-killing fly subfamily Phasiinae, we discovered C. continua for the… read more here.
Keywords: status; killing fly; highly variable; variable bug ... See more keywords
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113819
Abstract: The inhibition of glutaminyl cyclase (QC) may provide a promising strategy for the treatment of early Alzheimer's disease (AD) by reducing the amount of the toxic pyroform of β-amyloid (AβΝ3pE) in the brains of AD… read more here.
Keywords: glutaminyl cyclase; highly potent; potent human; cyclase ... See more keywords
Discovery of Highly Bioactive Peptides through Hierarchical Structural Information and Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c01006
Abstract: Peptide drugs play an essential role in modern therapeutics, but the computational design of these molecules is hindered by several challenges. Traditional methods like molecular docking and molecular dynamics (MD) simulation, as well as recent… read more here.
Keywords: information; hierarchical structural; molecular dynamics; discovery highly ... See more keywords
Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00475
Abstract: Thrombo-inflammation is closely associated with a few severe cardiovascular and infectious diseases. Factor XIIa (FXIIa) in the intrinsic coagulation pathway plays a pivotal role in the development of thrombo-inflammation and its inhibition has emerged as… read more here.
Keywords: potent covalent; thrombo inflammation; factor xiia; discovery highly ... See more keywords
Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01134
Abstract: USP7 is an attractive therapeutic target for cancers, especially for acute lymphoblastic leukemia (ALL) with wild-type p53. Herein, we report the discovery of XM-U-14 as a highly potent, selective and efficacious USP7 proteolysis-targeting chimera degrader.… read more here.
Keywords: potent selective; acute lymphoblastic; lymphoblastic leukemia; highly potent ... See more keywords
Discovery of Highly Selective CYP1B1 Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01181
Abstract: Tumor-drug resistance remains a critical challenge in pharmaceutical research. Recent studies have identified CYP1B1 as a potential target mediating paclitaxel resistance. In this study, we employed structure-based drug design to synthesize a series of thiazoleamide… read more here.
Keywords: resistance; highly selective; selective cyp1b1; discovery highly ... See more keywords
Synergistic Computational–Experimental Discovery of Highly Selective PtCu Nanocluster Catalysts for Acetylene Semihydrogenation
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b03539
Abstract: Semihydrogenation of acetylene (SHA) in an ethylene-rich stream is an important process for polymer industries. Presently, Pd-based catalysts have demonstrated good acetylene conversion (XC2H2), ho... read more here.
Keywords: highly selective; semihydrogenation; synergistic computational; experimental discovery ... See more keywords
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment
Sign Up to like & getrecommendations! Published in 2024 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c01440
Abstract: Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Unfortunately, targeting STAT3 with small molecules has proven to be very challenging, and for full activation of STAT3, the cooperative phosphorylation… read more here.
Keywords: cancer; highly selective; stat3 inhibitor; discovery highly ... See more keywords
The Importance and Discovery of Highly Connected Covalent Organic Framework Net Topologies.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c14458
Abstract: Furthering the field of synthetic organic chemistry from the discrete molecules regime to the extended structure regime, covalent organic frameworks (COFs) represent a new genre of crystalline porous materials featuring designability with molecular-level precision, well-defined… read more here.
Keywords: importance discovery; covalent; covalent organic; discovery highly ... See more keywords
Abstract 2385: Discovery of highly specific claudin 6 monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2385
Abstract: Claudin 6 (CLDN6) is an oncofetal tight junction protein involved in the cell-to-cell adhesion of epithelial and endothelial cell sheets. Although silenced in healthy adult human tissues, CLDN6 expression has been found in ovarian, gastric,… read more here.
Keywords: discovery; specific claudin; cldn6; highly specific ... See more keywords