Discovery of a Highly Active Catalyst for Hydrogenolysis of C−O Bonds via Systematic, Multi‐metallic Catalyst Screening
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900462
Abstract: Hydrogenolysis of C−O bonds is a highly challenging reaction with the most efficient catalysts based on bimetallic assemblies. Systematic studies to identify the optimum metal combination have not been performed and, therefore, we designed a… read more here.
Keywords: multi metallic; discovery highly; highly active; hydrogenolysis ... See more keywords
Discovery of a highly variable bug killing fly species, Clytiomya continua (Diptera: Tachinidae: Phasiinae), in Korea with discussion on its systematic status
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2021.02.008
Abstract: Abstract At present, the genus Clytiomya of the tribe Gymnosomatini includes four Palaearctic species, which exhibit high intraspecific variability. While studying Korean members of the bug-killing fly subfamily Phasiinae, we discovered C. continua for the… read more here.
Keywords: status; killing fly; highly variable; variable bug ... See more keywords
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113819
Abstract: The inhibition of glutaminyl cyclase (QC) may provide a promising strategy for the treatment of early Alzheimer's disease (AD) by reducing the amount of the toxic pyroform of β-amyloid (AβΝ3pE) in the brains of AD… read more here.
Keywords: glutaminyl cyclase; highly potent; potent human; cyclase ... See more keywords
Synergistic Computational–Experimental Discovery of Highly Selective PtCu Nanocluster Catalysts for Acetylene Semihydrogenation
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b03539
Abstract: Semihydrogenation of acetylene (SHA) in an ethylene-rich stream is an important process for polymer industries. Presently, Pd-based catalysts have demonstrated good acetylene conversion (XC2H2), ho... read more here.
Keywords: highly selective; semihydrogenation; synergistic computational; experimental discovery ... See more keywords
Abstract 2385: Discovery of highly specific claudin 6 monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2385
Abstract: Claudin 6 (CLDN6) is an oncofetal tight junction protein involved in the cell-to-cell adhesion of epithelial and endothelial cell sheets. Although silenced in healthy adult human tissues, CLDN6 expression has been found in ovarian, gastric,… read more here.
Keywords: discovery; specific claudin; cldn6; highly specific ... See more keywords
Discovery of highly potent HDAC8 PROTACs with anti-tumor activity.
Sign Up to like & getrecommendations! Published in 2023 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4348732
Abstract: Various diseases are deeply associated with aberrations in HDAC8 functions. These aberrations can be assigned to either structural functions or catalytic functions of HDAC8. Therefore, development of HDAC8 degradation inducers might be more promising than… read more here.
Keywords: highly potent; hdac8; activity; potent hdac8 ... See more keywords
Discovery of Highly Active Recombinant PNGase H+ Variants Through the Rational Exploration of Unstudied Acidobacterial Genomes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00741
Abstract: Peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidases (PNGases, N-glycanases, EC 3.5.1.52) are indispensable tools in releasing N-glycans from glycoproteins. So far, only a limited number of PNGase candidates are available for the structural analysis of glycoproteins and their glycan… read more here.
Keywords: active recombinant; highly active; pngase; pngase variants ... See more keywords