Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4494-1_18
Abstract: Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high potency while maintaining a desirable safety profile, having been matured and… read more here.
Keywords: strategies therapeutic; emerging strategies; antibody; discovery human ... See more keywords
Discovery of human scFvs that cross-neutralize the toxic effects of B. jararacussu and C. d. terrificus venoms.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.09.001
Abstract: Accidents involving venomous snakes are a public health problem worldwide, causing a large number of deaths per year. In Brazil, the majority of accidents are caused by the Bothrops and Crotalus genera, which are responsible… read more here.
Keywords: terrificus; discovery human; cross; human scfvs ... See more keywords
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.10.010
Abstract: Summary The peptidergic system is the most abundant network of ligand-receptor-mediated signaling in humans. However, the physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). Here we report the… read more here.
Keywords: human signaling; discovery human; protein coupled; coupled receptors ... See more keywords
Bioactivity-Guided Discovery of Human Carboxylesterase Inhibitors from the Roots of Paeonia lactiflora.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00464
Abstract: In a continuing search for potential inhibitors against human carboxylesterases 1A1 and 2A1 (hCES1A1 and hCES2A1), an EtOAc extract of the roots of Paeonia lactiflora showed strong hCES inhibition activity. Bioassay-guided fractionation led to the… read more here.
Keywords: bioactivity guided; roots paeonia; guided discovery; discovery human ... See more keywords
The discovery of human TSLP as a critical epithelial cytokine in type 2 immunity and allergic disease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0720-7
Abstract: Working on the function of a new cytokine always makes for exciting times. Vassili Soumelis and Yong-Jun Liu bring us back to the discovery and functional characterization of human TSLP, in the very stimulating environment… read more here.
Keywords: cytokine; human tslp; critical epithelial; discovery human ... See more keywords
The Inadvertent Discovery of Human Fetal Cell Microchimerism.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical chemistry"
DOI: 10.1373/clinchem.2017.273474
Abstract: Featured Article: Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci U S A 1996;93:705–8.2… read more here.
Keywords: human fetal; cell microchimerism; inadvertent discovery; fetal cell ... See more keywords