Discovery of imidazopyrrolopyridines derivatives as novel and selective inhibitors of JAK2.
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DOI: 10.1016/j.ejmech.2021.113394
Abstract: Herein, we describe the design, synthesis, and structure-activity relationships of a series of imidazopyrrolopyridines derivatives that selectively inhibit Janus kinase 2 (JAK2). These screening cascades revealed that 6k was a preferred compound, with IC50 values… read more here.
Keywords: imidazopyrrolopyridines derivatives; derivatives novel; discovery imidazopyrrolopyridines; novel selective ... See more keywords