Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
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DOI: 10.1021/jacs.9b10377
Abstract: The eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5'-end of mRNAs, stimulating the translation of proteins implicated in cancer cell growth and metastasis. eIF4E is a notoriously challenging target,… read more here.
Keywords: targeted eif4e; lysine targeted; discovery lysine; lysine ... See more keywords